Cellular Plexiform Fibrohistiocytic Tumor.
- Author:
Jee Young KIM
1
;
Misoo CHOI
;
Chan Hee NAM
;
Ji Seok KIM
;
MyungHwa KIM
;
Byung Cheol PARK
;
Seung Phil HONG
Author Information
1. Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea. zamoo97@naver.com
- Publication Type:Case Report
- Keywords:
Mesenchymal neoplasm;
Plexiform fibrohistiocytic tumor (PFHT)
- MeSH:
Actins;
Biopsy;
Child, Preschool;
Dermis;
Female;
Giant Cells;
Histiocytes;
Humans;
Islands;
Muscle, Smooth;
Myofibroblasts;
Neoplasm Metastasis
- From:Korean Journal of Dermatology
2015;53(5):396-399
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Plexiform fibrohistiocytic tumor (PFHT) is a rare mesenchymal neoplasm of intermediate malignancy and possibly of myofibroblast origin. It is morphologically divided into 3 groups: cellular, fibrous, and mixed. A 4-year-old girl presented with an irregular shaped subcutaneous mass on her left popliteal fossa for 6 months. The biopsy specimen showed multinodular tumor islands extending from dermis to subcutaneous layer, composed of histiocytes and osteoclast-like multinucleated giant cells, and circumscribed by fibrous tissue. Immunohistochemical staining was positive for CD68 in giant cells and histiocyte-like cells within tumor islands and faintly positive for smooth muscle actin around nodules. A cellular variant of PFHT was eventually diagnosed. Although PFHT comprises morphologically normal cells, it has the biological potential for malignant change and distal metastasis. Therefore, PFHT is categorized as a neoplasm of intermediate malignancy, and wide total excision with close follow-up is crucial.
