Effects of Antioxidant Supplementation on the Lipid Peroxidation and Antioxidative Enzyme Activities in Patients with Coronary Heart Disease.
10.4070/kcj.2001.31.11.1215
- Author:
Jae Eun JUN
1
;
Hyojee JOUNG
;
Byung Yeol CHUN
;
Young Sun CHOI
;
Wee Hyun PARK
;
Shung Chull CHAE
;
Kyung Eun SONG
;
Sung Hee CHO
Author Information
1. Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. jejun@knu.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article ; Clinical Trial
- Keywords:
Antioxidants;
Coronary disease;
Lipid peroxidation;
Clinical trials
- MeSH:
alpha-Tocopherol;
Antioxidants;
Ascorbic Acid;
beta Carotene;
Catalase;
Coronary Disease*;
Erythrocytes;
Glutathione Peroxidase;
Humans;
Lipid Peroxidation*;
Oxidative Stress;
Selenium;
Superoxide Dismutase;
Tocopherols;
Vitamin A
- From:Korean Circulation Journal
2001;31(11):1215-1224
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The purpose of this study was to evaluate whether antioxidant supplementation with tocopherol, vitamin C, beta-carotene, and selenium reduces lipid peroxide levels and increases antioxidative enzyme activities in patients with coronary heart disease. SUBJECTS AND METHODS: Eighty nine patients participated in a randomized, double-blind, placebo-controlled trial. The antioxidant group (45 patients) was given daily doses of tocopherol (400 IU), vitamin C (500 mg), beta-carotene (15 mg), and selenium (50 microgram) and the placebo group (44) received placebo. Thirty eight of the antioxidant group (84.4%) and thirty nine (88.6%) of the placebo group completed the 3-month supplementation. RESULTS: Serum levels of alpha-tocopherol, vitamin C and beta-carotene were significantly increased in the antioxidant group as compared to the placebo group (p<0.05), however, retinol was not. Thiobarbituric acid-reactive substances (TBARS) decreased significantly (0.6 nmol MDA/mL) in the antioxidant group as compared with the level (0.09 nmol MDA/mL) seen in the placebo group (p<0.05). Antioxidants did not affect the oxidized-LDL level. The activities of erythrocyte superoxide dismutase (SOD) significantly increased by 0.85 unit/mg hemoglobin in the antioxidant group versus 0.27 unit/mg hemoglobin in the placebo group (p<0.01), and the activities of erythrocyte catalase significantly decreased by 0.04 unit/mg hemoglobin versus 3.37 unit/mg hemoglobin (p<0.01). However, the activities of erythrocyte glutathione peroxidase (GPX) increased insignificantly by 0.09 unit/mg hemoglobin vs 0.1 unit/mg hemoglobin. CONCLUSION: These results suggest that antioxidant supplementation with tocopherol, vitamin C, beta-carotene and selenium in patients with coronary heart disease may provide a prophylactic effect against oxidative stress.
