Antibiotic Sensitivity Pattern of Pathogens from Children with UTI.
- Author:
Young Dae KWON
1
;
Myung Jin KIM
;
Hee Un KIM
;
Sei Ho OH
;
Jin Young SONG
;
Joon Tae KO
;
Ho Seok KANG
Author Information
1. Department of Pediatrics, Sunlin Hospital, Handong University, Pohang, Korea. pdoseho@hanmail.net
- Publication Type:Original Article
- Keywords:
Urinary tract infection(UTI);
Antibiotic sensitivity;
Extended-spectrum beta-lactamase(ESBL)
- MeSH:
Ampicillin;
Anti-Bacterial Agents;
Child*;
Enterococcus;
Escherichia;
Humans;
Incidence;
Medical Records;
Pneumonia;
Prevalence;
Proteus;
Retrospective Studies;
Urinary Tract
- From:Journal of the Korean Society of Pediatric Nephrology
2006;10(2):182-191
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We studied the degree of changes in antibiotic sensitivity toward causative organisms, prevalence and clinical manifestations of extended-spectrum beta-lactamase(ESBL)- producers of urinary tract infection(UTI) for a period of three years. This serves to provide useful information in selecting adequate drugs for the treatment of UTI. METHODS: We recruited 137 patients who grew more than 105 CFU/mL in their urine culture among 250 patients who visited and were admitted to Handong University's Sunlin Hospital for UTI treatment from January 2003 to December 2005. We retrospectively analyzed the data from the medical records. RESULTS: The common pathogenic organisms were Escherichia coli(65.0%), Klepsiella pneumoniae(14.0%), Enterococcus faecalis(5.8%) and Proteus vulgaris(2.9%) in consecutive order. The prevalence of ESBL-producers among isolated E. coli and K. pneumoniae was 4.5%(4 cases) and 14.3%(2 cases), respectively. The antibiotic sensitivity rates of E. coli were relatively high to amikacin(100%), imipenem(100%), ceftriaxone(95.5%) and tobramycin(91.4%) while relatively low to TMP/SMZ(55.4%), ampicillin/sulbactam(29.4%) and ampicillin (24.2%). CONCLUSION: The use of ampicillin, ampicillin/sulbactam and TMP/SMZ, which have been the first choices in the treatment of UTI, should be reconsidered due to the low sensitivity rates towards these antibiotics. Due to the high incidence and antibiotic tolerance of ESBL that might have risen from the development of new antibiotics and increased antibiotic use, it is necessary to consider changing the standard antibiotics that have been used in the treatment of UTI.
