A Case of Extensive Cerebral Venous Thrombosis in Childhood Nephrotic Syndrome.
- Author:
Chang Hee SON
1
;
Eun Hye LEE
;
Joo Hoon LEE
;
Young Seo PARK
Author Information
1. Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. yspark@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Cerebral venous thrombosis;
Nephrotic syndrome;
Childhood
- MeSH:
Brain;
Child;
Cyclosporine;
Edema;
Headache;
Humans;
Magnetic Resonance Imaging;
Male;
Nephrotic Syndrome*;
Proteinuria;
Recurrence;
Steroids;
Superior Sagittal Sinus;
Thrombosis;
Venous Thrombosis*;
Warfarin
- From:Journal of the Korean Society of Pediatric Nephrology
2006;10(2):238-243
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nephrotic syndrome in childhood is known to be associated with a hypercoagulable state and thromboembolic complications, among which cerebral venous thrombosis is a very rare and serious one, with only a few isolated reports in the literature. A 9-year-old boy with known nephrotic syndrome was admitted due to a relapse with massive proteinuria and generalized edema. He complained of a prolonged frontal headache. The enhanced brain magnetic resonance imaging(MRI) showed a high signal in the region of the superior sagittal sinus and right transverse sinus consistent with a thrombus. He was managed with steroids, cyclosporine and warfarin. His headache subsided 2 weeks later and proteinuria resolved 1 month later. An MRI 2 months later was normal. We describe this case and review the literature to emphasize the importance of recognizing this potentially life threatening complication and initiating anticoagulation therapy.
