Development of an Animal Experimental Model for a Bileaflet Mechanical Heart Valve Prosthesis.
10.3346/jkms.2004.19.1.37
- Author:
Suk Jung CHOO
1
;
Kun Il KIM
;
Nam Hee PARK
;
Jong Min SONG
;
In Cheol CHOI
;
Jee Yeon SHIM
;
Sang Kwon LEE
;
Young Joo KWON
;
Chang Nyung KIM
;
Jae Won LEE
Author Information
1. Department of Thoracic & Cardiovascular Surgery, Asan Medical Center, University of Ulsan, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Surgical instruments;
Prosthetic Valve;
Cardiopulmonary Bypass;
Hemodynamic Assessment;
Hemodynamic Processes
- MeSH:
Adrenergic beta-Agonists/pharmacology;
Animals;
Aorta/pathology;
Aortic Valve/*pathology;
Disease Models, Animal;
Dobutamine/pharmacology;
Dose-Response Relationship, Drug;
Heart Rate;
*Heart Valve Prosthesis;
Male;
Pressure;
*Prosthesis Implantation;
Support, Non-U.S. Gov't;
Swine;
Thoracic Arteries/pathology
- From:Journal of Korean Medical Science
2004;19(1):37-41
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to develop a pre-clinical large animal model for the in vivo hemodynamic testing of prosthetic valves in the aortic position without the need for cardiopulmonary bypass. Ten male pigs were used. A composite valved conduit was constructed in the operating room by implanting a prosthetic valve between two separate pieces of vascular conduits, which bypassed the ascending aorta to the descending aorta. Prior to applying a side-biting clamp to the ascending aorta for proximal grafting to the aortic anastomosis, an aorta to femoral artery shunt was placed just proximally to this clamp. The heart rate, cardiac output, Vmax, transvalvular pressure gradient, effective orifice area and incremental dobutamine stress response were assessed. A dose dependant increase with dobutamine was seen in terms of cardiac output, Vmax, and the peak transvalvular pressure gradient both in the native and in the prosthetic valve. However, the increment was much steeper in the prosthetic valve. No significant differences in cardiac output were noted between the native and the prosthetic valves. The described pre-clinical porcine model was found suitable for site-specific in-vivo hemodynamic assessment of aortic valvular prosthesis without cardiopulmonary bypass.
