The Outcomes of Hypertransfusion in Major ABO Incompatible Allogeneic Stem Cell Transplantation.
10.3346/jkms.2004.19.1.79
- Author:
Se Hoon PARK
1
;
Mark Hong LEE
;
Se Hoon LEE
;
Kyung Eun LEE
;
Jinny PARK
;
Joon Oh PARK
;
Kihyun KIM
;
Won Seog KIM
;
Chul Won JUNG
;
Young Hyuk IM
;
Won Ki KANG
;
Keunchil PARK
;
Seon Woo KIM
;
Kyoo Hyung LEE
;
Je Hwan LEE
Author Information
1. Division of Hematology and Oncology, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea. mlee@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Blood Transfusion;
Blood Group Incompatibility;
Hemolysis;
Hematopoietic Stem Cell Transplantation
- MeSH:
*ABO Blood-Group System;
Adolescent;
Adult;
*Blood Transfusion;
Erythrocytes/metabolism;
Erythropoiesis;
Female;
Hemoglobins/metabolism;
Hemolysis;
Human;
Male;
Middle Aged;
Retrospective Studies;
Stem Cell Transplantation;
Time Factors;
Transplantation, Homologous;
Treatment Outcome
- From:Journal of Korean Medical Science
2004;19(1):79-82
- CountryRepublic of Korea
- Language:English
-
Abstract:
Major ABO incompatibility may be potentially associated with immediate or delayed hemolysis and delayed onset of erythropoiesis in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). To determine if hemolysis can be prevented by the inhibition of graft erythropoiesis, we performed hypertransfusion and assessed red cell transfusion requirement and independence. Between October 1995 and December 2001, 28 consecutive patients receiving major ABO incompatible HSCT at Samsung Medical Center were hypertransfused to maintain their hemoglobin levels at 15 g/dL or more. We retrospectively compared the outcomes of these patients with those of 47 patients at Asan Medical Center whose target hemoglobin levels were 10 g/dL. Reticulocyte engraftment was significantly delayed in hypertransfused group (51 days vs. 23 days; p= .001). There was no significant difference in the total amount of red cells transfused within 90 days post-HSCT (25 units vs. 26 units; p= .631). No significant difference in the time to red cell transfusion independence was observed between the two groups (63 days vs. 56 days; p=.165). In conclusion, we failed to improve red cell transfusion requirement and independence in major ABO incompatible HSCT with hypertransfusion.
