Circulating Concentrations of C-Peptide and Colorectal Adenoma.
- Author:
Yoon Ji CHOI
1
;
Young Ha KIM
;
Chang Ho CHO
;
Sung Hi KIM
;
Jung Eun LEE
Author Information
- Publication Type:Original Article
- Keywords: C-peptide; Colorectal adenoma; Hyperinsulinemia
- MeSH: Adenoma*; Adult; C-Peptide*; Case-Control Studies; Colonoscopy; Fasting; Humans; Hyperinsulinism; Insulin; Logistic Models; Odds Ratio; Prevalence; Surveys and Questionnaires
- From:Clinical Nutrition Research 2014;3(1):17-23
- CountryRepublic of Korea
- Language:English
- Abstract: Hyperinsulinemia may increase the risk of colorectal neoplasia because of its mitogenic and antiapoptotic properties, which have a growth-promoting effect. We examined the association between circulating concentrations of C-peptide, a biomarker of insulin secretion, and colorectal adenoma prevalence in a case-control study of Korean adults. A total of 364 participants (112 cases and 252 controls) were included. Participants who underwent a colonoscopy completed questionnaires and provided blood samples. We used multivariate logistic regression models to obtain odds ratios (ORs) and 95% confidence intervals (CIs) for colorectal adenoma. Circulating concentrations of C-peptide were not associated with colorectal adenoma; the multivariate OR (95% CI) was 0.95 (0.51-1.75) comparing the highest tertile with the lowest tertile (p for trend = 0.91). When we used a conditional logistic regression model by fasting status and sex matching, there was still no association (OR = 0.92; 95% CI = 0.43-1.99) when comparing the highest tertile with the lowest tertile. We observed no association between circulating concentrations of C-peptide and colorectal adenoma prevalence in Korean adults.
