A Prospective Randomized Study on Two Dose Fractionation Regimens of High-Dose-Rate Brachytherapy for Carcinoma of the Uterine Cervix: Comparison of Efficacies and Toxicities Between Two Regimens.
10.3346/jkms.2004.19.1.87
- Author:
Taek Keun NAM
1
;
Sung Ja AHN
Author Information
1. Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Korea. ahnsja@chonnam.ac.kr
- Publication Type:Original Article ; Clinical Trial ; Randomized Controlled Trial
- Keywords:
Cervix Neoplasms;
Brachytherapy;
Dose Fractionation;
Prospective Studies
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Brachytherapy/*methods;
Carcinoma/mortality/*radiotherapy;
Cervix Neoplasms/mortality/*radiotherapy;
Combined Modality Therapy;
Disease-Free Survival;
*Dose Fractionation;
Female;
Human;
Middle Aged;
Prospective Studies;
Time Factors;
Treatment Outcome
- From:Journal of Korean Medical Science
2004;19(1):87-94
- CountryRepublic of Korea
- Language:English
-
Abstract:
To evaluate the toxicities and efficacies of two fractionation regimens of high-doserate brachytherapy in uterine cervical cancer, patients were stratified by stage Ib- IIa versus IIb-IVa, and randomly assigned to receive 3 Gy fractions (group A) or 5 Gy fractions (group B). External radiotherapy was performed using a 10 MV radiography with a daily 1.8 Gy up to 30.6 Gy to the whole pelvis, and then with a midline shield up to 45.0 Gy. Brachytherapy was performed with 3 Gy x 10 times or 5 Gy x5 times, and this was followed by booster brachytherapy of a smaller fraction to the residual tumor. Between August 1999 to July 2000, 46 patients were eligible. Median follow-up period was 42 months (5-49). The range of age was 37-83 yr (median, 58). The three-year disease-specific survival rates of group A (n=23) and B (n=23) were 90.5%, 84.9%, respectively (p=0.64). The three-year pelvic control rates of group A and B were 90.0% and 90.9%, respectively (p=0.92). The incidences of late complications of the rectum or bladder of grade 2 or greater in groups A and B were 23.8% and 9.1%, respectively (p=0.24). Our study showed that the results of two regimens were comparable. Fractionation regimen using 5 Gy fractions seems to be safe and effective, and offers shorter treatment duration.
