Micro-computed tomography analysis of changes in the periodontal ligament and alveolar bone proper induced by occlusal hypofunction of rat molars.
10.4041/kjod.2014.44.5.263
- Author:
Yasuhiro SHIMIZU
1
;
Jun HOSOMICHI
;
Saeko NAKAMURA
;
Takashi ONO
Author Information
1. Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. y.shimizu.orts@tmd.ac.jp
- Publication Type:Original Article
- Keywords:
Three dimensional scanner;
Computed tomography;
Histology;
Bone biology;
Occlusal stimuli;
Micro-computed tomography
- MeSH:
Animals;
Humans;
Incisor;
Male;
Molar*;
Periodontal Ligament*;
Rats*;
Rats, Wistar
- From:The Korean Journal of Orthodontics
2014;44(5):263-267
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To three-dimensionally elucidate the effects of occlusal hypofunction on the periodontal ligament and alveolar bone proper of rat molars by micro-computed tomography (micro-CT). METHODS: Occlusal function in the molar area was restricted by attaching an anterior bite plate on the maxillary incisors and a metal cap on the mandibular incisors of 5-week-old male Wistar rats for 1 week. The periodontal ligament space and alveolar bone proper around roots of the mandibular first molar were assessed by histology and micro-CT. RESULTS: The periodontal ligament space was narrower and the alveolar bone proper was sparser and less continuous in the hypofunction group than in the control group. Further, both the volume of the periodontal ligament and the volumetric ratio of the alveolar bone proper to the total tissue in the region of interest were significantly lower in the hypofunction group (p < 0.05). CONCLUSIONS: Occlusal hypofunction induces atrophic changes in the periodontal ligament and alveolar bone proper of rat molars.
