Kearns-Sayre Syndrome: 3 Case Reports and Review of Clinical Feature.
10.3349/ymj.2004.45.4.727
- Author:
Seong Bae PARK
1
;
Kyoung Tak MA
;
Koung Hun KOOK
;
Sang Yeul LEE
Author Information
1. The Institute of Vision Research, Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea. SYLee@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Atypical retinal pigmentary change;
kearns-sayre syndrome;
ptosis;
ragged-red fiber
- MeSH:
Adolescent;
Adult;
Atrophy;
Biopsy;
Blepharoptosis/*pathology;
Electrooculography;
Humans;
Kearns-Sayer Syndrome/*pathology;
Male;
Muscle, Skeletal/*pathology;
Ophthalmoscopes;
Retina/*pathology
- From:Yonsei Medical Journal
2004;45(4):727-735
- CountryRepublic of Korea
- Language:English
-
Abstract:
Kearns-Sayre syndrome, first described by Kearns and Sayre in 1958, is a rare disorder consisting of ptosis, limited movement of both eyes and atypical retinal pigmentary change (salt-pepper like appearance). Most cases have shown an increase in the concentration of mitochondria and ragged-red fiber under Gomori-trichrome staining on muscle biopsy. Occasionally, it is combined with other neurologic and endocrinologic symptoms such as ataxia, dementia, diabetes, and hyperaldosteronism. We recently experienced three cases of male teenaged patients who expressed the clinical features of Kearns-Sayre syndrome.
