Schizophrenia and Glutathione S-transferase P Gene Polymorphism.
- Author:
Chi Un PAE
1
;
Young Min LEE
;
Dae Hyun YANG
;
Jung Jin KIM
;
Hye Suk YU
;
Chang Uk LEE
;
Soo Jung LEE
;
Chul LEE
;
In Ho PAIK
Author Information
1. Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. knpsy@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Association study;
Glutathione S-transferase P gene (GSTP1) polymorphism;
Schizophrenia
- MeSH:
Alleles;
Clinical Coding;
Diagnostic and Statistical Manual of Mental Disorders;
Genotype;
Glutathione Transferase*;
Glutathione*;
Humans;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
2004;43(1):23-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study is aimed to test the association between the coding sequence functional polymorphism (I105 V) of glutathione S-transferase P gene (GSTP1) and schizophrenia. METHODS: Two hundred fourteen (214) patients with schizophrenia according to the DSM-IV criteria and one hundred ten (110) healthy controls were enrolled in this study. Patients and controls were biologically unrelated age and sex- matched native Koreans. Genotyping for the GSTP1 polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Genotype and allele distributions of the GSTP1 polymorphism in patients with schizophrenia were not significantly different from those of the controls. Comparisons of clinical variables also were not different according to genotype and allele distribution. CONCLUSION: The present study suggests that the GSTP1 polymorphism may not confer susceptibility to development of schizophrenia, at least in the Korean population.
