Early Pathologic Changes of Kidney after Intraperitoneal Challenge with Sodium Oxalate in Rat.
- Author:
Ki Hak SONG
1
;
Byung Kwon LEE
;
Kwang Jin KIM
;
Soon Won HONG
;
Hyeon Joo JEONG
Author Information
1. Yonsei University, Wonju college of Medicine, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
calcium oxalate crystal;
stone formation
- MeSH:
Animals;
Calcium Oxalate;
Dilatation;
Edema;
Inflammation;
Kidney*;
Necrosis;
Oxalic Acid*;
Rats*;
Sodium*
- From:Korean Journal of Urology
1997;38(12):1261-1267
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate the relationship between calcium oxalate stone formation and pathological change of the rat kidney, the early phases of calcium oxalate crystal formation in rat kidneys after intraperitoneal challenge with sodium oxalate were examined at various time interval. The number, size and distribution of the calcium oxalate particles, which were formed intraluminally in proximal tubule, depend on the pathological change according to the time interval after its injection. Tubular obstruction and dilatation due to cellular edema followed by necrosis of tubules and interstitial inflammation were related with increase in number and size of the calcium oxalate particles.
