Clinical Role of F-18 Fluorodeoxyglucose Positron Emission Tomography for Follow-up of Patients with Renal Cell Carcinoma.
10.4111/kju.2007.48.8.765
- Author:
Geon Hun KIM
1
;
Moon Ki JO
;
Gi Jeong CHEON
;
Hyun Moo LEE
Author Information
1. Department of Urology, Korea Cancer Center Hospital, Seoul, Korea. andrea@kcch.re.kr
- Publication Type:Original Article
- Keywords:
18F fluorodeoxyglucose;
Positron emission tomography;
Renal cell carcinoma
- MeSH:
Brain;
Carcinoma, Renal Cell*;
Diagnosis;
Electrons*;
Fluorodeoxyglucose F18;
Follow-Up Studies*;
Humans;
Magnetic Resonance Imaging;
Neoplasm Metastasis;
Nephrectomy;
Positron-Emission Tomography*;
Recurrence;
Thorax
- From:Korean Journal of Urology
2007;48(8):765-770
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the role of [(18)F]fluorodeoxyglucose-positron emission tomography(FDG-PET) for the follow-up of patients with a renal cell carcinoma(RCC), and compare FDG-PET with conventional imaging modalities, including computerized tomography(CT), chest PA, bone scan and brain magnetic resonance imaging(MRI). MATERIALS AND METHODS: FDG-PET and conventional imaging techniques, includingCT, chest PA, bone scan and brain MRI, were performed on 69 patients who had undergone a radical nephrectomy and/or metastatectomy, with a final pathological diagnosis of a RCC. The final diagnoses of recurrences/metastases were established from the histopathological or clinical findings. RESULTS: Recurrences and metastases were present at 47 sites(34 patients). The results of FDG-PET were true positive and false negative in 44 and 3 of the 47 sites, respectively. The results of conventional imaging techniques were true positive and false negative in 40 and 7 of the 47 sites, respectively. The results of FDG-PET were true negative and false positive in 34 and 1 of the 35 patients, respectively. The results of conventional imaging techniques were true negative and false positive in 30 and 5 of the 35 patients, respectively. Therefore, FDG-PET was more sensitive, specific and accurate than conventional imaging techniques for the follow-up of patients with a RCC. CONCLUSIONS: FDG-PET accurately detected the postoperative recurrences and metastases in patients with a RCC. FDG-PET may have a role in the follow-up of patients with a RCC.
