The Effect of Basic Fibroblast Growth Factor on the Vascularization of Porous Polyethylene Orbital Implant(Medpor(R)).
- Author:
Kyung Rak KIM
1
;
Chun Suk JUNG
;
Sung Kun CHUNG
Author Information
1. Department of Ophthalmology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. eyedoc@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Basic fibroblast growth factor;
Medpor(R);
Vascularization
- MeSH:
Fibroblast Growth Factor 2*;
Orbit*;
Orbital Implants;
Polyethylene*;
Rabbits
- From:Journal of the Korean Ophthalmological Society
2002;43(11):2258-2264
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the effect of basic fibroblast growth factor (bFGF) on the vascularization rate of Medpor(R), a synthetic polyethylene orbital implant. METHODS: Medpor(R), pretreated or untreated with bFGF (25 ng/ml), was inserted into one eye of 18 New Zealand white rabbits and removed at 1, 2, and 4 weeks after implantation, and stained with hematoxylineosin and Masson's trichrome. Degree of vascularization was classified into zone 1 (or=4.6 mm ingrowth). RESULTS: One and two weeks after implantation, the percentage of the vascularization area were 56.25% and 68.75% in bFGF-untreated group, while those of bGFG-treated group were 75% and 80.56% respectively, but there were no statistical difference between bFGF-untreated and treated group. However, four weeks after implantation it was significantly higher in bFGF-treated group (84.38%) than in bFGFuntreated group (66.25%) (P<0.05). CONCLUSIONS: BFGF enhanced more and early fibrovascular ingrowth of Medpor(R).
