Protective Effects of Viscoelastic Substances on air Bubble Damage During Phacoemulsification.
- Author:
Moon Jung KIM
1
;
Jung Won PARK
;
Shin Jung KANG
;
Hyung Lae KIM
;
Jae Bum LEE
;
Eung Kweon KIM
Author Information
1. Institute of Vision Research, Department of Ophthalmology, Yonsei University, Seoul, Korea. eungkkim@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Air bubbles;
Corneal endothelium;
Viscoelastics
- MeSH:
Actins;
Chondroitin Sulfates;
Cornea;
Endothelial Cells;
Endothelium;
Endothelium, Corneal;
Eye Banks;
Humans;
Hyaluronic Acid;
Microscopy, Electron, Scanning;
Phacoemulsification*;
Viscoelastic Substances*
- From:Journal of the Korean Ophthalmological Society
2002;43(11):2273-2279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine whether viscoelastic materials are effective to protect the corneal endothelium from air bubble damage. METHODS: Human eye bank (n=12) and rabbit (n=22) eyes underwent a standardized phacoemulsification procedure with or without viscoelastic material [1% sodium hyaluronate (Healon(R)), 1.4% sodium hyaluronate (Healon GV(R)), 3% sodium hyaluronate with 4% chondroitin sulfate (Viscoat(R))]. The integrity of the endothelium was examined after the procedure with F-actin staining and scanning electron microscopy (SEM). RESULTS: In the phacoemulsification experiment without viscoelastic material, with Healon, and with Healon GV, the endothelium of both human and rabbit corneas had many areas of cell loss in a pattern consistent with air bubble damage. But with Viscoat, endothelial cells remained intact. CONCLUSIONS: We found that Viscoat was effective to protect the endothelium from air bubble damage. Viscoat seems to protect the endothelium by acting as a physical barrier.
