Therapeutic Efficacy of Ciclopirox Nail Lacquer in the Treatment of Onychomycoses.
- Author:
Young Ho WON
;
Jee Bum LEE
;
Seung Chul LEE
;
Inn Ki CHUN
- Publication Type:Original Article
- Keywords:
Ciclopirox;
Nail Lacquer;
Onycgomycoses
- MeSH:
Adhesives;
Character;
Fungi;
Humans;
Lacquer*;
Onychomycosis*;
Sensation
- From:Korean Journal of Dermatology
1995;33(6):1079-1084
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Ciclopirox 8% nail lacquer is a new topical antifungal agent which is character ized by excellent penetration into the nail plate to the infected koratin and remains there for a prolonged period. We per formed a st,udy to assess the therapeutic efficacy and safety of ciclopirox 8% nail lacquer in the treatment of onychomycoses. METHODS: We used 20 satients with onychomycoses, which was confirmed by KOH ancl fungus culture. The ciclopirox nail lacquer was applied once daily for 1 month, and followed by two times weekly for the next 5 months. The clinical observat.ion was perforrned every month for any clinical improvement and side-dffects. The involved percent of a target nail was measured by using a adhesive tape at.ached to the selected nail plate. All involved nails(n=68) were also evaluated by a severity score(sever>50%. moderate 25-50%, mild<25%). RESULTS: Seventeen patients were finally assessed because of the deletion of 3 patients througl loss of contact. The involved percent of target nail was significantly decreased from 57.4% at baseline to 27.9% througli the 6 month-treatment(p<0.01, ANOVA). The total reduced precent of target nail involvement at the end of the treatment was 52+22% on average. The precent of severly involved nail(>50%) in all 68 involved nails was also decreased from 56% at baseline to 7% by the end of the treatment The mycologieal cure rate was 82.4% by the end of the treatment. The overall efficaor assessed by the physician and patients was improvement by 82.4% Tolerability was excellent or good in all patients, but cosmetic acceptance was good or excellen by 53%. Only one patient complained of a prickling sensation, but no systemic adverse effect were found. CONCLUSION: These data suggest that ciclopirox 8% nail lacquer may be safe and effective ir the treatment of onychomvcoses.
