Use of low-dose sulodexide in IgA nephropathy patients on renin-angiotensin system blockades.
- Author:
Byeong Yun YANG
1
;
Hee Seon LEE
;
Sang Heon SONG
;
Ihm Soo KWAK
;
Soo Bong LEE
;
Dong Won LEE
;
Eun Young SEONG
Author Information
1. Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. shsong@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
IgA nephropathy;
Proteinuria;
Sulodexide
- MeSH:
Follow-Up Studies;
Glomerulonephritis, IGA;
Glycosaminoglycans;
Humans;
Immunoglobulin A;
Proteinuria;
Renin-Angiotensin System;
Retrospective Studies
- From:Kidney Research and Clinical Practice
2012;31(3):163-169
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Despite using renin-angiotensin system (RAS) blockades, some of the patients with immunoglobulin A (IgA) nephropathy often had persistent proteinuria of more than 500mg/d. They need to be managed further by alternative methods to halt the progression of the disease; these methods could also be applied safely over a long period of time. In this context, sulodexide has been studied for the management of diabetic nephropathy. METHODS: A retrospective review was carried out involving 20 patients with IgA nephropathy who had been taking sulodexide (50mg daily) as an add-on therapy together with an optimal dose of RAS blockades during 2008-2009. We evaluated the proteinuria reduction rates and renal function changes. RESULTS: During 11.1+/-72.7 months of follow-up duration, urinary protein-to-creatinine ratio (UPCR) decreased for 1.57+/-0.6 to 1.17+/-0.7 g/g (P=0.032). Twenty-five percent of the patients showed a greater than 50% reduction of UPCR, and 40% had a UPCR of less than 1.0g/g at their final observations. The analysis of the factors contributing to the effect found that a higher pretreatment UPCR showed a significant correlation with the UPCR decrease (r=0.45, P=0.047). Neither the adverse effects nor the renal function impairments were documented during the management. CONCLUSION: Low-dose sulodexide has an additional modest antiproteinuric effect on IgA nephropathy undergoing RAS blockade therapy.
