The Relationship of the Hypertension, Insulin Resistance, and Metabolic Syndrome in the Serum Uric Acid Level.
10.4070/kcj.2004.34.9.874
- Author:
Tae Woo YOO
1
;
Ki Chul SUNG
;
Young Choon KIM
;
Sang Tai HWANG
;
Se Yong OH
;
Hun Sub SHIN
;
Byung Jin KIM
;
Bum Soo KIM
;
Jin Ho KANG
;
Man Ho LEE
;
Jung Ro PARK
;
Hyang KIM
;
Kyu Beck LEE
;
Hyun Young LHEE
;
Seung Ho RYU
;
Dong Geuk KEUM
Author Information
1. Department of Internal Medicine, Division of Cardiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. mdkcsung@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Uric acid;
Hypertension;
Insulin resistance;
Metabolic syndrome
- MeSH:
Apolipoproteins;
Blood Glucose;
Blood Pressure;
Cohort Studies;
Fasting;
Hypertension*;
Insulin Resistance*;
Insulin*;
Korea;
Prevalence;
Reference Values;
Uric Acid*;
Waist Circumference
- From:Korean Circulation Journal
2004;34(9):874-882
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVE: The relationship between serum uric acid and metabolic syndrome variables has not been reported in Korea. Therefore, whether the circulating levels of serum uric acid are independently related to hypertension, insulin resistance and the variables of metabolic syndrome were assessed. SUCJECTS AND METHODS: A total of 53,477 health screen examinees were enrolled and divided into four groups (Quartile 1:<4.2 mg/dL, Quartile 2:4.2-5.29 mg/dL, Quartile 3:5.3-6.29 mg/dL, Quartile 4:>6.29 mg/dL) according to their serum uric acid level. The blood pressure, lipid profiles, fasting plasma glucose, waist circumference, HOMA, high sensitivity CRP and apolipoprotein were compared between the four groups. RESULTS: There was a positive association between blood pressure and the serum uric acid level (p<0.001). After adjustment for covariates the prevalence of hypertension due to uric acid was 1.192 (95% CI, 1.038-1.368 p=0.013), and 1.408 (95% CI, 1.221-1.623 p<0.001) times higher in subjects in the third and fourth uric acid level quartiles, respectively, compared to the subjects in the first quartile. Insulin resistance and metabolic syndrome variables were positively correlated with the serum uric acid level. The number of metabolic syndrome variables was also increased with an elevated serum uric acid level. CONCLUSION: Our study suggests that serum uric acid levels were independently associated with hypertension, insulin resistance and the variables of metabolic syndrome in the Korean population. Although the serum uric acid level was normal value, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies.
