Overlap Syndrome of Antisynthetase Syndrome and Rheumatoid Arthritis: A Case Report.
- Author:
Hui Won JANG
1
;
You Jung HA
;
Yoon KANG
;
Kwang Hoon LEE
;
Yong Beom PARK
;
Soo Kon LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. sookonlee@yuhs.ac
- Publication Type:Case Report
- Keywords:
Polymyositis;
Jo-1 antibody;
Rheumatoid arthritis;
Overlap syndrome
- MeSH:
Antibodies, Antinuclear;
Antibody Formation;
Arthritis;
Arthritis, Rheumatoid;
Connective Tissue Diseases;
Fever;
Hand;
Humans;
Joints;
Lung Diseases, Interstitial;
Male;
Middle Aged;
Myositis;
Polymyositis
- From:Korean Journal of Medicine
2011;81(5):673-679
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The antisynthetase syndrome is characterized by anti-Jo-1 antibody production, interstitial lung disease, inflammatory muscle disease, and, in many cases, fever, polyarthritis, Raynaud's phenomenon, and mechanic's hands. Joint signs and symptoms occur in up to 90% of patients with antisynthetase syndrome, occasionally as the initial manifestations. Although visual inspection of the hands shows changes that are highly suggestive of rheumatoid arthritis, notable differences exist. Antisynthetase syndrome is a predominantly nonerosive arthropathy with subluxations of the distal interphalangeal joints. It manifests as overlap syndrome with other connective tissue diseases. However, overlap syndrome of antisynthetase syndrome and rheumatoid arthritis is rare. We treated a 51-year-old male patient with overlap syndrome of antisynthetase syndrome and rheumatoid arthritis, and report the case with a review of the literature.
