A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data.
- Author:
Hongseok TAE
1
Author Information
1. Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA, The Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA. mbio94@naver.com
- Publication Type:Note
- Keywords:
visualization;
DNA methylation;
bisulfite sequencing;
epigenetics;
MethylDraw
- MeSH:
Base Sequence;
Cytosine;
DNA;
DNA Methylation;
Epigenomics;
Gene Expression;
Methylation;
Phenotype;
Sulfites
- From:Genomics & Informatics
2011;9(3):136-137
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of bisulfite-treated DNA is the most efficient method to identify methylated sites, several tools to map sequencing reads on a reference are available. But tools to visualize and to interpret the methylation level of methylation sites are currently insufficient. Herein, we present a novel tool to visualize the methylation level of CpG sites.
