The Effect of H1-Receptor Antagonist on Hemodynamic Change during Anesthesia.
10.4097/kjae.2006.51.4.395
- Author:
Tae Soo HAHM
1
;
Chung Soo KIM
;
Myong Shin KOO
;
Byung Seop SHIN
;
Hee Youn HWANG
;
Sang Min LEE
;
Hyun Sung CHO
Author Information
1. Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hscho@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
antihistamine;
chlorpheniramine maleate;
hemodynamic change
- MeSH:
Administration, Intravenous;
Anesthesia*;
Cardiac Output;
Chlorpheniramine;
Heart Rate;
Hemodynamics*
- From:Korean Journal of Anesthesiology
2006;51(4):395-399
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
baseline for safe use of a drug. RESULTS: SVR and PVR failed to show statistically significant changes. Heart rates were increased only at 2 minute after administration of chlorpheniramine maleate. Blood pressures were increased but returned to basal level within 4 minutes. Cardiac output showed statistically significant increase until 8 minutes. However, the changes of hemodynamic values were maintained within 20% of basal levels. CONCLUSIONS: Chlorpheniramine maleate is observed to cause statistically significant hemodynamic change after intravenous administration during anesthesia. But the changes were within 20% of basal levels, and we can safely use chlorpheniramine maleate 8 mg IV in the view of hemodynamic changes.
