Inhibiting Effect of Amiodarone to Protective Action against Ischemia/Reperfusion Injury Induced by Ischemic Preconditioning.
10.4097/kjae.2006.51.4.455
- Author:
Eun Hye KOO
1
;
Chung Guk PARK
;
Sang Ho LIM
;
Young Cheol PARK
Author Information
1. Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. negul88@empal.com
- Publication Type:Original Article
- Keywords:
amiodarone;
ischemic preconditioning;
isolated heart;
myocardial protection;
reperfusion arrhythmia
- MeSH:
Amiodarone*;
Arrhythmias, Cardiac;
Blood Pressure;
Heart Rate;
Ischemic Preconditioning*;
Myocardial Ischemia
- From:Korean Journal of Anesthesiology
2006;51(4):455-462
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
odarone. Isovolumetric left ventricular end systolic pressure (LVESP), left ventricular end diastolic pressure (LVEDP), dP/dtMAX and heart rate were measured. RESULTS: Group II showed more recovered LVESP, less developed ventricular stiffness, more preserved coronary effluent flow, earlier termination of arrhythmia and smaller infarct size than Group I. Group III showed preserved LVESP and dP/dtMAX, less developed ventricular stiffness, shortest arrhythmia sustaining time, smallest infarct size among all groups. These myocardial protective effects were abolished in Group IV. CONCLUSIONS: We observed that IPC and amiodarone administration, each has myocardial protective effects against myocardial ischemia, but when they are dealt at the same time, their beneficial effects diminished.
