Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates.
- Author:
Ji Young KIM
1
;
Su Jin CHO
;
Hae Soon KIM
;
Hye Sook PARK
;
Eun Ae PARK
Author Information
1. Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. pea8639@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Insulin like growth factor-I;
Fetal growth
- MeSH:
Adiponectin;
Birth Weight;
Body Mass Index;
Female;
Fetal Development;
Head;
Humans;
Infant;
Infant, Newborn;
Insulin-Like Growth Factor I;
Male;
Parturition;
Umbilical Cord;
Weight Gain
- From:Journal of the Korean Society of Neonatology
2008;15(1):38-43
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. METHODS: Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). RESULTS: The mean cord serum APN was 29.2+/-10.46 microgram/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26+/-21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. CONCLUSION: APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.
