Efficacy of Sufentanil during Laryngeal Microscopic Surgery.
10.4097/kjae.2006.50.2.168
- Author:
Chul Ho CHANG
1
;
Sang Beom NAM
;
Tae Dong KWON
;
Hyun Kyu LEE
;
Kum Hee CHUNG
;
Youn Woo LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. ywleepain@yumc.yonsei.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
bispectral index;
cardiovascular response;
laryngeal microscopic surgery;
sufentanil
- MeSH:
Analgesics;
Anesthesia;
Anesthesia, General;
Anesthetics;
Blood Pressure;
Heart Rate;
Humans;
Naloxone;
Pharyngitis;
Postoperative Complications;
Postoperative Period;
Sufentanil*
- From:Korean Journal of Anesthesiology
2006;50(2):168-172
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Various anesthetic agents have been used in laryngeal microscopic surgery, because the airway is shared with the surgeon, there is a short operation duration and intense cardiovascular stimulation occurs during the surgery. Sufentanil is superior than other anesthetic agents in blocking the cardiovascular response to the airway stimulation and a short duration of effects. METHODS: Thirty patients undergoing elective laryngeal microscopic surgery were randomized to receive sufentanil 0.125 microgram/kg (group 1, n = 10), sufentanil 0.25 microgram/kg (group 2, n = 10) or sufentanil 0.5 microgram/kg (group 3, n = 10). The bispectral index score, blood pressure, heart rate, recovery time from general anesthesia, the need for additional analgesics and naloxone and the postoperative complications associated with sufentanil were measured. RESULTS: The bispectral index, blood pressure and heart rate were similar in the three groups. Only four patients in group 3 required naloxone (P < 0.05). Three patients in group 1, one in group 2 and 0 in group 3 required an additional dose of sufentanil. Postoperative sore throat was detected in 6 patients in the immediate postoperative period and in 8 patients 6 hours after the end of anesthesia in group 1 (P < 0.05). CONCLUSIONS: Sufentanil is an effective analgesic for attenuating the cardiovascular responses of airway stimulation in laryngeal microscopic surgery. In addition, sufentanil 0.25 microgram/kg is an appropriate dose for the rapid recovery and attenuation of the cardiovascular response in laryngeal microscopic surgery.
