The Effects of Prophylactic Metoclopramide and Induction with Propofol on Postoperative Nausea and Vomiting.
10.4097/kjae.2006.50.2.179
- Author:
Hyun Hee PARK
1
;
Kwan Sik PARK
;
Sook Young LEE
;
Oi Gyeong CHO
;
Jae Hyung KIM
;
Jin Soo KIM
;
Dong Wook SHIN
Author Information
1. Department of Anesthesiology and Pain Medicine, School of Medicine, Ajou University, Suwon, Korea. anesylee@ajou.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
laparoscopic cholecystectomy;
metoclopramide;
postoperative nausea and vomiting (PONV);
propofol
- MeSH:
Anesthesia;
Antiemetics;
Cholecystectomy, Laparoscopic;
Humans;
Incidence;
Metoclopramide*;
Nausea;
Postoperative Nausea and Vomiting*;
Propofol*;
Thiopental
- From:Korean Journal of Anesthesiology
2006;50(2):179-183
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Postoperative nausea and vomiting (PONV) are common problems in patients undergoing a laparoscopic cholecystectomy. This study evaluated the effect of prophylactic metoclopramide (MCP) and induction with propofol on PONV. METHODS: 165 patients undergoing laparoscopic cholecystectomy were randomly divided into four groups. Groups 1 (control group) and 2 were inducted with thiopental sodium. Groups 3 (propofol group) and 4 were inducted with propofol. Prophylactic metoclopramide 10 mg i.v. was administered in Groups 2 (MCP group) and 4 (propofol + MCP group). The incidence of PONV, the need for rescue antiemetics, adverse events, and the nausea severity scores were assessed at 0 to 1 hour and at 1 to 24 hours postoperatively. RESULTS: During the first 24 hours after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 41.5%, 29.3%, 30.3% and 23.3%, respectively. There was no significant difference between the groups. During the period, 1 hour to 24 hours, after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 36.6%, 17.4%, 27.5% and 14.4%, respectively. The incidence of PONV in Group 4 was significantly lower than in Group 1 (P < 0.05). CONCLUSIONS: In patients with laparoscopic cholecystectomy, a combination of prophylactic metoclopramide administration and induction with propofol was found to reduce the incidence of PONV by about 22.6% during the period 1 hour to 24 hours after anesthesia.
