Studies for the Surface Desensitizing Activity of SS-cream on the Rabbit Cornea.
- Author:
Zhong Cheng XIN
1
;
Young Deuk CHOI
;
Hun Gu HAH
;
Hyung Ki CHOI
Author Information
1. Department of Urology, Yonsei University College Of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
corneal sensitivity;
rabbit;
SS-cream;
lidocaine;
premature ejaculation
- MeSH:
Anesthetics;
Angelica;
Cornea*;
Lidocaine;
Premature Ejaculation;
Reflex;
Semen
- From:Korean Journal of Urology
1996;37(8):872-876
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
SS-cream is a topical agent for treating the premature ejaculation (PE) which was made up with extracts of 9 oriental herbs (Ginseng Radix alba, Angelicae gigantic Radix, Cistanchis Herba, Zanthoxylli Fructus, Torilidis Semen, Asiasari Radix, Caryophylli Flos, Cinnamoni Cortex and Bufonis Veneum). According to the active compositions, the main mechanism of SS- cream on PE was thought to be the local desensitizing effect. In order to realize the pharmacological action of SS-cream on PE, we performed the corneal sensitivity test with SS- cream and lidocaine in the rabbit (n=80). Both SS-cream and lidocaine inhibited the pin-prick induced corneal reflex dose-dependently (p<0.001). The anesthetic effect of lidocaine was appeared 5 minutes after the application and the duration of action persisted for 10 minutes. The intensities of desensitizing effect of SS- cream were almost same with those of 2% lidocaine, but the time of onset and duration of action was longer than 2% lidocaine. The time of onset was 10 minutes and the duration of action was persisted for more than 30 minutes. There were no local histopathologic changes after the application of SS-cream and lidocaine. With these result, we can conclude that SS-cream has a desensitizing effect on the cornea of rabbit. The believed main pharmacologic mechanism of SS-cream on PE is the desensitization of the Local Surface sensitivity.
