Metabolic Syndrome and the Risk for Chronic Kidney Disease among Korean Women.
10.4082/kjfm.2009.30.2.98
- Author:
Sun Kyung CHAE
1
;
Jee Soo LEE
;
Jee Hyun CHUN
;
Hye Soon PARK
Author Information
1. Department of Family Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. hyesoon@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Metabolic Syndrome;
Chronic Kidney Disease;
Glomerular Filtration Rate
- MeSH:
Adult;
Aged;
Alcohol Drinking;
Body Mass Index;
Cardiovascular Diseases;
Cholesterol;
Coronary Disease;
Fasting;
Female;
Glomerular Filtration Rate;
Glucose;
Humans;
Hypertension;
Hypertriglyceridemia;
Lipoproteins;
Logistic Models;
Obesity, Abdominal;
Odds Ratio;
Renal Insufficiency, Chronic;
Risk Factors;
Smoke;
Smoking;
Tertiary Healthcare
- From:Korean Journal of Family Medicine
2009;30(2):98-105
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Metabolic syndrome (MetS), characterized by abdominal obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, high blood pressure, and high fasting glucose level, is a common risk factor for cardiovascular diseases and associated complications. We examined the relationship between the metabolic syndrome and risk of chronic kidney disease (CKD) in Korean women. METHODS: We used data from 10,170 women, aged 30-89 years, who had visited a health examination center at a tertiary care hospital in 2006. The data were studied cross-sectionally. MetS was identified using the modified criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). CKD was defined as an estimated GFR < 60 ml/min per 1.73 m2. The multivariable-adjusted (adjustment for age, education, body mass index (BMI), alcohol drinking, smoking, previous coronary heart disease, menopauses and physical inactivity) odds ratio of CKD (95% CI) associated with each component of the metabolic syndrome was calculated using the logistic regression models. RESULTS: A total of 1,039 participants have MetS. The multivariable-adjusted odds ratios (OR) of CKD in participants with MetS, hypertriglyceridemia and high blood pressure compared with participants without such factors were 2.68 (95% CI, 1.77-4.06), 1.96 (95% CI, 1.34-2.88), and 2.00 (95% CI, 1.38-2.89). Compared with the participants with no MetS traits, those with one, two, equal to or more than three traits of MetS had OR of CKD of 1.24 (95% CI, 0.75-2.06), 1.56 (95% CI, 0.89-2.75), and 2.18 (95% CI, 1.21-3.93), respectively. CONCLUSION: We found that Korean women with MetS had an increased risk for developing CKD. Finally, earlier identification and management of MetS might improve patient health and prevent progression of CKD.