A Case of Acute Myeloid Leukemia Developing after Treatment for Brucellosis with Pancytopenia.
- Author:
Sun Hyung KIM
1
;
Kyung Pyo KIM
;
Sanghoon HAN
;
Young Ree KIM
;
Sung Ha KANG
Author Information
- Publication Type:Case Report
- Keywords: Brucellosis; Pancytopenia; Acute leukemia
- MeSH: Bone Marrow; Bone Marrow Examination; Brucella; Brucellosis*; Fever; Humans; Leukemia, Myeloid, Acute*; Pancytopenia*; Pneumonia; Zoonoses
- From:Laboratory Medicine Online 2015;5(3):157-160
- CountryRepublic of Korea
- Language:Korean
- Abstract: Human brucellosis is an important zoonotic disease and has a wide clinical spectrum. Nonspecific hematologic abnormalities related to brucellosis are frequently found, but pancytopenia is uncommon. Malignant diseases have been infrequently reported as a rare cause of pancytopenia in patients with brucellosis. We describe a patient with brucellosis and pancytopenia who was later diagnosed with acute myeloid leukemia. A 71-yr-old man was admitted to a hospital with fever and pancytopenia. Brucella was cultured from blood, and the bone marrow findings were in accordance with brucellosis. The patient's clinical symptoms improved; however, he still showed pancytopenia after completion of medical treatment. After approximately 6 months, he was readmitted with pneumonia and pancytopenia. The second bone marrow examination revealed hypercellular marrow with increased number of blasts. The chromosome analysis showed 46,XY,trp(8)(q11.2q22)[8]/46,idem,del(7)(q22)[12]. The patient was diagnosed with acute myeloid leukemia with myelodysplasia-related changes. He refused further evaluation and therapy, and subsequently died while receiving conservative treatment.
