Central N omega-nitro-L-arginine Methyl Ester Does not Influence Lithium-induced c-Fos and Conditioned Taste Aversion.
10.3349/ymj.2003.44.5.869
- Author:
Jeong Won JAHNG
1
;
Si Ho CHOI
;
Dong Goo KIM
;
Thomas A HOUPT
Author Information
1. Department of Pharmacology, Yonsei University College of Medicine, Shin chon-dong, Seodaemun-gu, Seoul, Korea. dgkimpharm@yumc.yonsei.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Conditioned taste aversion;
lithium chloride;
c-Fos;
nitric oxide;
rat;
intracerebroventricular injection
- MeSH:
Animals;
Avoidance Learning/*drug effects/physiology;
Brain/*physiology;
Conditioning (Psychology) /*drug effects/physiology;
Immunohistochemistry;
Injections, Intraventricular;
Lithium/*pharmacology;
Male;
NG-Nitroarginine Methyl Ester/*pharmacology;
Nitric Oxide/physiology;
Proto-Oncogene Proteins c-fos/*analysis;
Rats;
Rats, Sprague-Dawley;
Support, Non-U.S. Gov't;
Taste/*drug effects/physiology
- From:Yonsei Medical Journal
2003;44(5):869-874
- CountryRepublic of Korea
- Language:English
-
Abstract:
LiCl at doses sufficient to induce conditioned taste aversion (CTA) causes c-Fos expression in the brain regions implicated in CTA formation. It has been reported that nitric oxide (NO) may play a role in CTA learning and LiCl increases both the synthesis and activity of NO synthase (NOS) in the brain. In this study, we examined the effect of central N omega-nitro-L- arginine methyl ester (L-NAME) on the brain c-Fos expression and CTA learning induced by lithium in rats. In the results, intracerebroventricular L-NAME given prior to lithium did not change either the lithium-induced CTA or c-Fos in the relevant brain regions. This suggests that the brain NO system may not be involved in the neuronal activation during lithium-induced CTA formation.
