Inherited Vitamin K Deficiency: Case Report and Review of Literature.
10.3349/ymj.2003.44.5.923
- Author:
Zerrin ORBAK
1
;
Ayse SELIMOGLU
;
Hakan DONERAY
Author Information
1. Department of Pediatrics, Ataturk Universitesi Dis Hekimligi Fakultesi, Periodontoloji Anabilim Dali, 25240 Erzurum, Turkey. zerrinorbak@yahoo.com
- Publication Type:Case Report
- Keywords:
Hereditary vitamin K deficiency;
osteopenia;
treatment;
osteocalcin
- MeSH:
Bone Density;
Bone Diseases, Metabolic/etiology;
Human;
Infant;
Male;
Osteocalcin/blood;
Prothrombin Time;
Vitamin K Deficiency/blood/complications/*genetics
- From:Yonsei Medical Journal
2003;44(5):923-927
- CountryRepublic of Korea
- Language:English
-
Abstract:
Vitamin K is the cofactor for the hepatic carboxylation of glutamic acid residues in a number of proteins including the procoagulants factors ll, Vll, lX, and X. The role of vitamin K in normal bone function is not fully understood. Inherited deficiency of vitamin K dependent coagulation factors is a rare bleeding disorder reported only in a few patients. Here we present an 18-month old child who presented with osteopeni due to inherited vitamin K deficiency. While the patient had high bone specific alkaline phosphatase and parathyroid hormone levels and low osteocalcin and bone mineral density values, with the regular supplementation of vitamin K all the mentioned parameters returned to normal values.
