Behcet's Disease: The First Mongolian Case in Literature Showing HLA B51, MICA Gene Type *5/*6.
10.3349/ymj.2003.44.5.935
- Author:
Yae Lee CHUNG
1
;
Dong Sik BANG
;
Eun So LEE
;
Sung Nack LEE
;
Jee Won MOK
;
Kyung Sook PARK
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Shin chon-dong, Seodaemun-gu, Seoul, Korea. dbang@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Behcet's disease;
mongolian;
HLA B51;
MICA genotype
- MeSH:
Adult;
Alleles;
Behcet Syndrome/*genetics/immunology;
Genotype;
HLA-B Antigens/*genetics;
Histocompatibility Antigens Class I/*genetics;
Human;
Male
- From:Yonsei Medical Journal
2003;44(5):935-938
- CountryRepublic of Korea
- Language:English
-
Abstract:
Behcet's disease is a chronic multi-systemic disease of unknown origin that includes mucocutaneous, ocular, cardiac, vascular, renal, gastrointestinal, neurologic and cutaneous involvement. The disease is spread throughout the world, but it is most prevalent in the eastern Mediterranean region-along the Silk Road-, and in Japan, China, and Korea. Recently, we treated a Mongolian patient who had complete-type Behcet's disease. As far as we know, this case is the first report of a Mongolian with Behcet's disease in the English literature. HLA typing in this patient revealed A2, A24; B51, B35; Cw4, Cw7; DR9, DR11. Study of the MICA genetype showed *5, *6 positive. Our data provided adequate evidence, from an epidemiological aspect, to support the belief that Behcet's disease is most prevalent along the old Silk Road.
