Reversible Posterior Leukoencephalopathy Syndrome in a Patient withSystemic Lupus Erythematosus Treated with Cyclosporine.
10.4078/jkra.2007.14.3.291
- Author:
Jae Dae SHIN
1
;
Ja Young SON
;
Dae Young KIM
;
Jin Hong PARK
;
Gun Woo KIM
;
Eun Joo SONG
;
Ji Min KIM
;
Kyung Hoon KIM
;
Eon Jeong NAM
;
Young Mo KANG
Author Information
1. Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea. gunwoo@fatima.or.kr
- Publication Type:Case Report
- Keywords:
Reversible posterior leukoencephalopathy syndrome;
Systemic lupus erythematosus;
Cyclosporine
- MeSH:
Autoimmune Diseases;
Azathioprine;
Brain;
Cerebellum;
Cyclosporine*;
Edema;
Female;
Headache;
Humans;
Hypertension;
Hypertensive Encephalopathy;
Lupus Erythematosus, Systemic;
Neuroimaging;
Occipital Lobe;
Posterior Leukoencephalopathy Syndrome*;
Rabeprazole;
Renal Insufficiency;
Seizures;
Temporal Lobe;
Vision Disorders
- From:The Journal of the Korean Rheumatism Association
2007;14(3):291-296
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Reversible posterior leukoencephalopathy syndrome (RPLS) is characterized clinically by headache, seizure, altered mental status and visual impairment. Neuroimaging shows reversible white matter edema predominantly in the parietal and occipital lobes. RPLS has been associated with a variety of conditions, including hypertensive encephalopathy, renal failure, immunosupressive therapy, and autoimmune diseases such as systemic lupus erythematosus (SLE). We report a young woman of SLE presented with headache, generalized tonic-clonic seizure and altered mental status, after taking azathioprine and cyclosporine. The brain magnetic resonance images showed bilateral hyperintensitiy in the posterior parietal, occipital, temporal lobes and cerebellum on T2-weighted images and fluid attenuated inversion recovery images, whereas diffusion-weighted images showed isointensity in the same distribution. The patient was improved clinically and radiologically one week after the control of hypertension and discontinuation of cyclosporine.
