An Analysis of the Ultrasound Findings of False Negative Cases for an Initial Ultrasound-guided Fine Needle Aspiration Biopsy (FNAB).
10.3348/jkrs.2007.57.3.213
- Author:
Jee Young KIM
1
;
So Lyung JUNG
;
Bum Soo KIM
;
Kook Jin AHN
;
Seong Tae HAHN
Author Information
1. Department of Radiology, College of Medicine, The Catholic University of Korea, Korea. sljung1@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid, ultrasonography;
Biopsy, fine-needle;
Thyroid, neoplasms;
Thyroid nodules;
Thyroid disease
- MeSH:
Biopsy*;
Biopsy, Fine-Needle*;
Carcinoma, Papillary;
Diagnosis;
Humans;
Retrospective Studies;
Thyroid Diseases;
Thyroid Nodule;
Ultrasonography*
- From:Journal of the Korean Radiological Society
2007;57(3):213-218
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To analyze the ultrasonographic (US) findings of thyroid nodules that yielded false negative results after an initial ultrasound-guided fine needle aspiration biopsy (FNAB). MATERIALS AND METHODS: Between August 2003 and February 2006, 389 patients with 405 thyroid nodules received a repeat US-guided FNAB. We retrospectively reviewed the US findings, cytology results and postsurgical pathological results. The cytology diagnoses were classified as benign, a suspicious malignancy, a follicular neoplasm, a papillary carcinoma, and a non-diagnostic result. The US findings of the thyroid nodules were analyzed with regard to size, internal content, shape, margin, echogenecity, and calcification pattern. RESULTS: Of the 405 thyroid nodules, 17 nodules were false negative. The major US findings of these nodules were a solid internal component in 16 nodules, hypoechogenicity or marked hypoechogenicity in 14 nodules, microcalcifications in 12 nodules, an ovoid to round shape in 9 nodules and a well-defined smooth margin in 9 nodules. CONCLUSION: An repeat US-guided FNAB should be performed if the thyroid nodules have one of the malignant US features such as hypoechogenecity or marked hypoechogenecity, a microcalcification, a taller than wide shape or a well-defined spiculate margin although the cytology results indicated a benign lesion. In addition, thyroid nodules with findings of a well-defined smooth margin, ovoid to round shape, and solid internal component might also be subject to a repeat US-guided FNAB to exclude a malignancy.
