Expression of e-cadherin with correlation to clinicopathologic parameters in oral squamous cell carcinoma.
- Author:
Jae Myoung SHIN
1
;
Young Sill KIM
;
Chang Hyen KIM
;
Sung Woon PYO
Author Information
1. Department of Oral and Maxillofacial Surgery, The Catholic University, of Korea. spyo@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Oral squamous cell carcinoma;
E-cadherin;
Prognostic factors
- MeSH:
Basement Membrane;
Cadherins*;
Carcinoma, Squamous Cell*;
Cell Adhesion;
Lymph Nodes;
Neoplasm Metastasis;
Prognosis
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2005;31(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It becomes more concerned that the cell adhesion molecule plays an important role in the process of malignant transformation and tumor behaviors including invasive growth and metastasis. It is postulated if the expression of adhesion molecule is reduced in tumor tissue, the tumor cell will be undifferentiated and lose their cell adhesion ability and polarity. So the tumor cells lost the adhesion of cell to cell and to basement membrane that they became more aggressive. Reduced cadherin expression enhances invasiveness through infiltrative growth and metastasis of tumor cells is well known and mostly accepted in many epithelia tumors. We explored the expression of E-cadherin by immunohistochemical staining in 50 oral squamous cell carcinomas and investigated the correlation between the expression of E-cadherin and clinicopathologic parameters and prognosis. The expression of E-cadherin was reduced in 40/50(80%) of primary tumors, and 21/22(95.5%) of lymph nodes. The reduced expression of the E-cadherin was associated with lymph node metastasis(P=0.029), invasive mode(P=0.030) and marginal status(P=0.038). Survival analysis showed that predictive period of E-cadherin reduced group(37 months) was lower than that of E-cadherin preserved group(60 months), but there was no statistical significant difference.
