Myasthenia Gravis in Two Brothers with Identical HLA Genotype.
- Author:
Jei KIM
1
;
Hee Jung SONG
;
Jae Moon KIM
Author Information
1. Department of Neurology, Chungnam National University Hospital, Taejon, Korea.
- Publication Type:Original Article
- Keywords:
Familial myasthenia gravis;
HLA genotype;
Autoimmune disease
- MeSH:
Adolescent;
Autoimmune Diseases;
Genotype*;
Humans;
Leukocytes;
Myasthenia Gravis*;
Neuromuscular Junction;
Siblings*
- From:Journal of the Korean Neurological Association
1999;17(3):452-455
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction having multigene control. Correlation with human leukocyte antigen (HLA) genotype in MG had been reported in sporadic and familial cases. We investigated HLA genotype of two myasthenic brothers, at ages 13 and 15 years old. There was no family history of myasthenia gravis. Their ages of onset were 10 and 15 years of age, respectively. Identical subtypes in HLA analyses were found, A30, A31, B13, B61, Cw3, Cw6, DRB1*04, DRB1*07, DQA1*02, DQA1*03, DQB1*03, DQB1*02 in both of them. We report two myasthenic siblings with identical HLA type that has not been reported previously.
