Interaction between Causative Factors of Cervical Cancer and BARD-1 (BRCA-associated ring domain-1) Polymorphism.
- Author:
Jin Hwi KIM
1
;
Sung Jong LEE
;
Keun Ho LEE
;
Chan Joo KIM
;
Sung Eun NAMKOONG
;
Jong Sup PARK
Author Information
1. Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea. jspark@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
BARD-1;
Single nucleotide polymorphism;
Cervical cancer
- MeSH:
Alleles;
Carcinogenesis;
Cervical Intraepithelial Neoplasia;
Child;
Coitus;
DNA;
Education;
Female;
Humans;
Polymorphism, Single Nucleotide;
Risk Factors;
Smoke;
Smoking;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
2005;48(7):1698-1707
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to identify interaction between causative factors of cervical cancer and BARD-1 (BRCA1 associated ring domain-1) polymorphism on cervical carcinogenesis in Korean women. METHODS: We evaluated 1,347 patients composed of women who had cervical cancer (n=337) and cervical intraepithelial neoplasia (n=308) and normal control healthy women (n=702) from October 2000 until November 2001. The single nucleotide polymorphisms (SNPs) of BARD-1 were evaluated from extracted DNA of peripheral blood with automatic DNA sequencer. The difference of each SNP between normal controls and patients was evaluated in the adjusted environmental background. RESULTS: In environmental aspect, the cervical cancer increased in the women who had the lower level of education, smoking history, the younger age of the first sexual intercourse, and the more child-bearing . The women who had BARD V507M (Arg/Arg) showed 1.6 fold increased risk in cervical cancer than the women who had BARD V507M (G/G), (G/A)(p=0.0433). And the risk increased with BARD R378S (C/C) among who have environmental risk factors compared with BARD R378S (G/G), (G/C) allele positive who have no environmental risk factors. CONCLUSION: We found that the level of education, the age at first intercourse, and the number of children were the independent risk factors in cervical carcinogenesis. The specific combination of BARD-1 and gene-environmental interactions were significantly noted in the cervical carcinogenesis in Korean women.
