Effects of Hormone Therapy on Serum hs-CRP levels in Surgically Menopaused Women.
- Author:
Ji Yeon KIM
1
;
Ki Hyung KIM
;
Kyu Sup LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. kuslee@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
hs-CRP;
Hormone therapy;
Menopause;
Lipid
- MeSH:
C-Reactive Protein;
Cholesterol;
Cholesterol, LDL;
Female;
Humans;
Menopause;
Plasma
- From:Korean Journal of Obstetrics and Gynecology
2005;48(7):1752-1759
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the effects of hormone therapy (HT) on high-sensitivity C-reactive protein (hs-CRP) in surgically menopaused women. METHODS: In this study, 156 healthy women were enrolled. After surgical menopause, 28 women were receiving HT and 32 women were not for 3 months, 28 women were receiving and 32 women were not for 1 year. Control group included 36 healthy premenopausal women not receiving HT. The effect of HT on plasma levels of hs-CRP and lipids were investigated. RESULTS: Mean hs-CRP concentrations were significantly higher in surgically menopaused women receiving HT than premenopausal women (premenopausal: 0.069+/-0.080 mg/dL, HT for 3 months: 0.095+/-0.079 mg/dL, HT for 1 year: 0.159+/-0.313 mg/dL, p<0.05). Mean hs-CRP concentrations were also higher in surgically menopaused women not receiving HT than premenopausal women (premenopausal: 0.069+/-0.080 mg/dL, 3 months after surgical menopause: 0.108+/-0.215 mg/dL, 1 year after surgical menopause: 0.081+/-0.146 mg/dL, p>0.05). There was no statistically significant difference between receiving HT group and not receiving HT group in 3 months and 1 year after surgical menopause. Total cholesterol and LDL cholesterol were significantly lower in surgically menopaused women receiving HT than not receiving HT for 3 months and 1 year (total cholesterol; 191.3+/-44.7 in HT group, 227.1+/-24.5 in no HT group for 3 months after surgical menopause: 191.9+/-29.4 in HT group, 218.2+/-34.4 in no HT group for 1 year after surgical menopause, LDL cholesterol; 117.5+/-25.7 in HT group, 129.1+/-22.5 in no HT group for 3 months after surgical menopause: 120.6+/-26.2 in HT group, 136.6+/-32.1 in no HT group for 1 year after menopause). CONCLUSION: hs-CRP was increased in surgically menopaused women than premenopausal women, however, there was no significant changes in hs-CRP between HT group and no HT group for 3 months and 1 year.
