Successful salvage treatment of acute graft-versus-host disease after liver transplantation by withdrawal of immunosuppression: a case report.
10.14701/kjhbps.2016.20.1.38
- Author:
Wei QIU
1
;
Guo Yue LV
;
Chao JIANG
;
Ping ZHANG
;
Xiao Dong SUN
;
Xiao Ju SHI
;
Xue Yan LIU
;
Guang Yi WANG
Author Information
1. Department of Hepato-biliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, China. wgymd@sina.com
- Publication Type:Case Report
- Keywords:
Graft-versus-host disease;
Liver transplantation;
Drug-induced liver injury
- MeSH:
Anti-Bacterial Agents;
Blood Cell Count;
Diagnosis;
Drug-Induced Liver Injury;
Exanthema;
Fever;
Graft vs Host Disease*;
Humans;
Immunosuppression*;
Liver Function Tests;
Liver Transplantation*;
Liver*;
Liver, Artificial
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2016;20(1):38-43
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acute graft-versus-host disease (GVHD) following liver transplantation is a rare but fatal complication. The correct diagnosis and management of GVHD after liver transplantation are still major challenges. Herein, we reported successful salvage treatment of acute GVHD by withdrawal of immunosuppression in a patient who presented with fever, skin rashes, and decreased blood cell counts after liver transplantation. This case highlights the need for awareness of drug-induced liver injury if liver function tests are elevated during treatment, especially in patients taking multiple potentially hepatotoxic drugs, such as broad-spectrum antibiotics. When occurs, an artificial liver support system is a useful tool to provide temporary support of liver function for the patient in the event of drug-induced liver injury.
