The efficacy of thymopentin in the treatment of atopic dermatitis.
- Author:
Hyeong Don BANG
;
Hyun Seung LEE
;
Phil Soo AHN
;
Dae Hun SUH
;
Kyung Chan PARK
;
Kyu Han KIM
- Publication Type:Original Article
- Keywords:
thymopentin;
atopic dermatitis
- MeSH:
Body Surface Area;
Dermatitis, Atopic*;
Humans;
Injections, Subcutaneous;
Thymopentin*
- From:Journal of Asthma, Allergy and Clinical Immunology
1998;18(4):640-646
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Thymopentin(TP-5) is an immunomodulatory agent which may be a promising new drug in the treatment of patients with severe atopic dermatitis. OBJECTIVE: The aim of this study was to evaluate the efficacy of thymopentin for treatment of severe atopic dermatitis. MATERIAL AND METHOD: Fifteen patients with severe atopic dermatitis received subcutaneous injections of 50mg thymopentin three times per week for 6 weeks. Clinical extent and severity parameters were assessed at baseline, at regular intervals during therapy and 4 weeks posttherapy. Use of antihistamine and topical steroid were permitted. RESULT: Significant reduction in severity scores and body surface area involvement was observed and no significant side effects were noted(p<0.05). CONCLUSION: Thymopentin may be considered to be an effective adjunctive therapeutic agent in the treatment of severe atopic dermatitis. Further studies will be needed to determine the action mechanism of thymopentin.
