Lymphocytic Interstitial Pneumonitis Associated with Epstein-Barr virus in Systemic Lupus Erythematosus and Sjgren's Syndrome: Complete remission with corticosteroid and cyclophosphamide.
- Author:
Ho Kee YUM
1
;
Eun Soon KIM
;
Kyung Sun OK
;
Hye Kyung LEE
;
Soo Jeon CHOI
Author Information
1. Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Lymphocytic interstitial pneumonitis (LIP);
Systemic Lupus Erythematosus (SLE);
Sj gren's syndrome;
Epstein-Barr virus
- MeSH:
Case Report;
Cyclophosphamide/therapeutic use;
Female;
Glucocorticoids, Synthetic/therapeutic use;
Herpesviridae Infections/*complications;
*Herpesvirus 4, Human;
Human;
Immunosuppressive Agents/therapeutic use;
Lung Diseases, Interstitial/*complications/drug therapy;
Lupus Erythematosus, Systemic/*complications;
Middle Age;
Prednisone/therapeutic use;
Sjogren's Syndrome/*complications
- From:The Korean Journal of Internal Medicine
2002;17(3):198-203
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lymphocytic interstitial pneumonitis (LIP) is characterized by diffuse bilateral pulmonary infiltrations in both lower lobes. Pleomorphic lymphohistiocytes including mature lymphocytes, variable admixture of plasma cells and other mononuclear cells infiltrate within the pulmonary interstitium, ranging from widened septa to confluent masses. We report a case of LIP associated with Epstein-Barr virus in a patient with SLE and Sj gren's syndrome. A 50-year-old woman was admitted with insidious onset of progressive dyspnea for 20 days. She suffered from arthritis 10 years earlier without specific diagnosis. A radiography of chest has showed bilateral consolidative infiltrations with pleural effusion in both lower lung fields. Open lung biopsy documented lymphocytic interstitial pneumonitis which expressed Epstein-Barr virus genome in situ hybridization study. Following corticosteroid and cyclophosphamide therapy, clinical symptoms and radiologic infiltrations gradually remitted.
