Effect of GM-CSF on Neutropenia Induced by Chemotherapy or Immunotherapy in Patients with Urologic Malignancy.
- Author:
Sung Hyun JEON
1
;
Sung Goo CHANG
Author Information
1. Department of Urology, School of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
GM-CSF;
Neutropenia;
Chemotherapy;
Immunotherapy
- MeSH:
Arthralgia;
Drug Therapy*;
Eosinophils;
Fever;
Granulocyte-Macrophage Colony-Stimulating Factor*;
Headache;
Humans;
Immunotherapy*;
Leukocyte Count;
Monocytes;
Mortality;
Neutropenia*;
Neutrophils;
Urticaria
- From:Korean Journal of Urology
2002;43(3):208-212
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Purpose: Neutropenia is a major factor contributing to morbidity and mortality in patients undergoing chemotherapy for cancer. The efficacy and complications of GM- CSF (Granulocyte-Macrophage colony stimulating factor) on the neutropenia induced by chemotherapy or immunotherapy were evaluated in patients with a urologic malignancy. Material and Methods: Twenty-nine patients with a histologically confirmed urologic malignancy, who presented with neutropenia during either chemotherapy or immunotherapy, were given a fixed dose (400microgram) of GM-CSF subcutaneously for three to fifteen days. Twenty-nine patients with neutropenia were given GM-CSF for 50 cycles. The patients were evaluated by means of a complete blood cell count, white cell and differential counts. The mean time to response was 2.3 days. The statistical significance of the differences was calculated using a paired t test. RESULTS: GM-CSF treatment in patients with neutropenia resulted in an increase in the mean neutrophil count, the eosinophil count, and the monocyte count. Complications of GM-CSF included fever (76%), GI problems (19%), headache (14%), bone pain (14%), arthralgia (10%), and urticaria (5%). CONCLUSIONS: GM-CSF may be useful in reducing the toxicity of chemotherapy. Therefore, GM-CSF can be used to increase the effect of chemotherapy without delaying or stopping treatment as a result of neutropenia.
