Experimental Study on Hyperplasia of Urinary Bladder Epithelium Induced by N-Butyl-N-(4-Hydroxybutyl) Nitrosamine in Rats.
- Author:
Wun Jae KIM
1
;
Young Kyoon KIM
Author Information
1. Department of Urology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
bladder tumor;
N-Butyl-N-(4-Hydroxybutyl) nitrosamine;
carcinogen
- MeSH:
Animals;
Diet;
Diet, High-Fat;
Epithelium*;
Female;
Humans;
Hyperplasia*;
Rats*;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Korean Journal of Urology
1986;27(2):219-227
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperplasia of the uninary bladder epithelium in Wistar strain female rats after administration of 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN) was examined histologically and the effect of fat diet on the development of hyperplasia of the urinary bladder was studied. Hyperplasia of the urinary bladder epithelium was consistently observed after 4 weeks, and its extent increased with the period of BBN administration. Some of the hyperplastic lesion, showed a tendency to regress following removal of the carcinogenic stimuli. High fat diet has no effect on hyperplastic change of the urinary bladder in rats.
