Two Cases of FSGS Maintaining Renal Function by Long Term Cyclosporine Treatment.
- Author:
Soon Kil KWON
1
;
Sang Hyun KIM
;
Su Hee KIM
;
Eun Joo PARK
;
Eun kyung LEE
;
Su Kil PARK
Author Information
1. Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.
- Publication Type:Case Report
- Keywords:
Cyclosporine;
Steroid resistant FSGS
- MeSH:
Azotemia;
Biopsy;
Cyclosporine*;
Edema;
Humans;
Proteinuria;
Renal Dialysis
- From:Korean Journal of Nephrology
2004;23(1):158-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cyclosporine can cause remission of 60% in steroid resistant FSGS, but its responses are variable. Now we report two cases of steroid resistant FSGS who are maintaining remission using cyclosporine continuous therapy. The first patient had been failed several times of steroid therapy, had edema, azotemia and severe proteinuria. We used steroid pulse therapy then maintenance dose of oral cyclosporine to reduce proteinuria for more than 6 years. He has been received cyclosporine therapy up to now and maintaining normal renal function. The second patient had severe azotemia who needed hemodialysis but after cyclosporine therapy, he recovered his renal funciton. The findings of renal biopsies in one patient after 6 years of cyclosporine therapy revealed that there was no improvement of sclerosing glomeruli, then we guess that maintenance therapy of cyclosporine might need for lifelong period.
