Expressions of MMP-2, MMP-9, TIMP-1, and TIMP-2 as prognostic factors in endometrial cancer.
10.3802/kjgo.2008.19.1.57
- Author:
Jong Ryeol CHOI
1
;
Tae Hwa LEE
;
Young Lim OH
;
Chun Jun LEE
;
Won Gyu KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea. kwg@kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Endometrial cancer;
Matrix metalloproteinase;
Tissue inhibitors of metalloproteinase;
Prognostic factor
- MeSH:
Basement Membrane;
Connective Tissue;
Endometrial Neoplasms;
Extracellular Matrix;
Female;
Homeostasis;
Immunohistochemistry;
Lymph Nodes;
Matrix Metalloproteinases;
Metalloproteases;
Neoplasm Metastasis;
Peptide Hydrolases;
Tissue Inhibitor of Metalloproteinase-1;
Tissue Inhibitor of Metalloproteinase-2
- From:Korean Journal of Gynecologic Oncology
2008;19(1):57-67
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Homeostasis of the extracellular matrix (ECM) is maintained by the action of a specific system of proteolytic enzymes known as matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP). The MMP/TIMP system regulates the composition and turnover of ECM to control the site and extent of connective tissue remodeling. In pathologic conditions, MMP play a key role in degradation of basement membrane and extracellular matrix, and is responsible for cancer invasion, progression and metastasis. The aim of this study is to evaluate the correlation between expressions of MMP/TIMP and clinicopathologic factors in endometrial cancer. METHODS: Expressions of MMP-2, MMP-9, TIMP-1, and TIMP-2 were assessed by immunohistochemistry in a total of 55 endometrial cancers and were analyzed by the correlation between expressions of MMP/TIMP and clinicopathologic factors in endometrial cancer. RESULTS: Expression rates of MMP-2,-9, TIMP-1, and TIMP-2 were 71.7%, 54.9%, 41.2%, and 76.5% respectively. Expression of MMP-2 was correlated with the group of positive lymph node metastasis in endometrial cancer (p=0.04). Specially, coexpression of MMP-2 and TIMP-2 was significantly more frequent in the group of positive lymph node metastasis (p<0.01) and the group of positive peritoneal CONCLUSION: The expressions of MMP and TIMP were not a significant difference in survival analysis, but this study was recognized that the coexpression MMP-2 and TIMP-2 is correlated with lymph node metastasis and positive peritoneal cytology.
