A Case of Reactive Plasmacytosis Mimicking Multiple Myeloma in A Patient with Primary Sjogren's Syndrome.
10.3346/jkms.2005.20.3.506
- Author:
Jisoo LEE
1
;
Ji Eun CHANG
;
Young Joo CHO
;
Woon Seop HAN
Author Information
1. Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea. leejisoo@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Sjogren's Syndrome;
Plasma Cells;
Plasmacytosis;
B Cell Differentiation
- MeSH:
Aged;
Antigens, CD19/analysis;
Antigens, CD27/analysis;
Bone Marrow Examination;
Diagnosis, Differential;
Female;
Fluorescent Antibody Technique/methods;
Humans;
Multiple Myeloma/*pathology;
Plasma Cells/chemistry/*pathology;
Sjogren's Syndrome/*pathology
- From:Journal of Korean Medical Science
2005;20(3):506-508
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease with welldocumented association of lymphoid malignancies during the progress of the disease. Although several types of malignancy and pseudomalignancy have been reported in pSS, low-grade non-Hodgkin's lymphomas are the most frequently observed. Reactive plasmacytosis mimicking myeloma is a very rare condition in association with pSS. We describe a 72-yr-old woman with pSS who presented with hypergammaglobulinemia, and extensive bone marrow and lymph node plasmacytosis, which mimicked multiple myeloma. In this patient, there was an abnormal differentiation of memory B cells to plasma cells in the peripheral blood suggesting underlying pathogenetic mechanism for this condition.
