Ultra-Structural Changes in the Retinal Pigment Epithelium Following a Long Term Topical Application of Beta-Blocker.
- Author:
Kyung Yeul LEE
1
;
Kyoo Won LEE
;
Duk Kee HAHN
Author Information
1. Department of Ophthalmology, Yeungnam University, School of Medicine, Daegu, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Ciliary Body;
Cytoplasm;
Epithelium;
Mitochondria;
Rabbits;
Retinal Pigment Epithelium*;
Retinaldehyde*;
Vacuoles
- From:Journal of the Korean Ophthalmological Society
1987;28(3):575-581
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ultra-structural changes in the retinal pigment epithelium in both pigmented and albino rabbits following a long term topical application of beta-adrenergic blocker were observed. One drop of 1% Befunolol hydrochloride solution was instilled into the conjunctival cul-de-sac twice daily in one eye of the animals. In the retinal pigment epithelium, mitochondria became swollen and numerous vaculoes were formed in the cytoplasm. The widening of the basal infolding were noted in both pigmented and albino rabbits. These changes were more remarkable in 7 months than 3 months. Furthermore, it was much more remarkable in the pigmented rabbits. Some degenerative changes were noted in the inner segment of photo-receptors of albino rabbits in 7 months. These swollen mitochondria and vacuole formations were also observed in the non-pigmented epithelium of the ciliary body.
