Cytomegalovirus Retinitis in a Child with Acute Lymphoblastic Leukemia.
- Author:
Youn Hui KIM
1
;
Sang Kook KIM
Author Information
1. Department of Ophthalmology, Chungbuk National University College of Medicine, Cheongju, Korea. simple521@chungbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Acute lymphoblastic leukemia;
CMV retinitis;
Ganciclovir
- MeSH:
Bone Marrow;
Child*;
Cicatrix;
Cytomegalovirus Retinitis*;
Cytomegalovirus*;
Drug Therapy;
Exudates and Transudates;
Ganciclovir;
Humans;
Immunoglobulin G;
Immunoglobulin M;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Recurrence;
Retina;
Retinal Hemorrhage;
Retinaldehyde;
Retinitis;
Serologic Tests
- From:Journal of the Korean Ophthalmological Society
2006;47(6):1009-1015
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of cytomegalovirus (CMV) retinitis in a child who had been managed by immunosuppressive chemotherapy for acute lymphoblastic leukemia (ALL). METHODS: An 8-year-old boy who had been managed by immunosuppressive chemotherapy for ALL was referred to the ophthalmologic clinic because of blurred vision in his right eye. Fundus examination showed hard exudates and white retinal leaion in the macular area of the right eye, white retinal lesion accompanied with retinal hemorrhage and exudates in the midperipheral retina of the left eye. Serologic tests demonstrated a positive response of CMV antibody IgG and a negative response of CMV antibody IgM. CMV was isolated upon the culture of bone marrow and peripheral blood. Immunosuppressive chemotherapy was discontinued and ganciclovir was administered. RESULTS: Administration of ganciclovir led to clinical stabilization of the retinitis lesion that was accompanied by scarring. We were able to discontinue the administration of ganciclovir after the retinal lesions were resolved, and no recurrence of CMV retinitis was noted. CONCLUSIONS: Ganciclovir treatment was clinically effective in improving CMV retinitis in an immunocompromised child with ALL. In addition, the improved systemic immune function achieved by discontinuing immunosuppressive chemotherapy permitted discontinuation of anticytomegalovirus therapy.
