Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng.
10.5625/lar.2017.33.2.105
- Author:
Young Hwan BAN
1
;
Yeseul CHA
;
Jieun CHOI
;
Eun Suk AN
;
Ji Young LEE
;
Nu Ry HAN
;
Da Woom SEO
;
Gooyoung JUNG
;
Da Hye JEONG
;
Man Hee RHEE
;
Ehn Kyoung CHOI
;
Yun Bae KIM
Author Information
1. College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea. solar93@cbu.ac.kr
- Publication Type:Original Article
- Keywords:
Mountain ginseng;
adventitious root;
ginsenoside;
platelet aggregation;
blood flow
- MeSH:
Animals;
Aspirin;
Cholesterol;
Collagen;
Ethanol;
Ginsenosides;
In Vitro Techniques;
Panax*;
Platelet Aggregation;
Rats;
Thrombosis;
Triglycerides
- From:Laboratory Animal Research
2017;33(2):105-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl₃-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl₃-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg₃ improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.
