Glutathione S-transferase M1, T1 and P1 Gene Polymorphisms and Carotid Atherosclerosis in Korean Patients with Rheumatoid Arthritis.
- Author:
Jae Hong PARK
1
;
Ahmed EL-SOHEMY
;
Seok Chol JEON
;
Suk Kyu PARK
;
Jung Won BYUN
;
Hye Soon LEE
;
Tae Hwan KIM
;
Jae Bum JUN
;
Dae Hyun YOO
;
Sang Cheol BAE
Author Information
1. Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
Atherosclerosis;
Glutathione S-transferase;
Polymorphism
- MeSH:
Arthritis, Rheumatoid*;
Atherosclerosis;
Carotid Artery Diseases*;
Carotid Artery, Common;
Female;
Genotype;
Glutathione Transferase*;
Glutathione*;
Humans;
Inflammation;
Polymorphism, Genetic;
Risk Factors;
Smoke;
Smoking;
Ultrasonography
- From:The Journal of the Korean Rheumatism Association
2003;10(2):166-175
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We assessed the contribution of genetic polymorphisms of glutathione S-transferase M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1, Ile105Val) to carotid atherosclerosis in 40 postmenopausal rheumatoid arthritis (RA) women without histories of smoking. METHODS: We measured mean intima-media thickness (IMT) and plaque of the common carotid arteries by ultrasonography, and evaluated relations among the known risk factors for atherosclerosis, genetic polymorphisms, RA outcomes and markers of inflammation. RESULTS: Subjects with the GSTT1-null genotype had greater IMT (p<0.05). On univariate analysis, carotid IMT was positively associated with age, systolic BP, antihypertensive drug use and the GSTT1-null genotype (p<0.05). When compared to subjects with a double- positive GSTM1/T1 genotype, IMT in subjects with concurrent lack of the GSTM1 and GSTT1 gene was significantly increased (p=0.008). CONCLUSION: This study suggests that the GSTT1-null genotype might have an interaction with carotid atherosclerosis related to RA in Korean postmenopausal RA women free of smoking history.
