Febrile Urinary Tract Infections Caused by Community-Acquired Extended-Spectrum beta-Lactamase-Producing and-Nonproducing Bacteria: A Comparative Study.
10.14776/piv.2015.22.1.29
- Author:
Do Hee AHN
1
;
Kyu Won KIM
;
Hye Kyung CHO
;
Han TCHAH
;
In Sang JEON
;
Eell RYOO
;
Yong Han SUN
Author Information
1. Department of Pediatrics, Graduate School of Medicine, Gachon University, Incheon, Korea. hkcho@gilhospital.com
- Publication Type:Comparative Study ; Original Article
- Keywords:
Urinary tract infection;
Extended-spectrum beta-lactamase
- MeSH:
Anti-Bacterial Agents;
Bacteria*;
beta-Lactamases;
Child;
Data Collection;
Escherichia coli;
Fever;
Humans;
Klebsiella;
Medical Records;
Retrospective Studies;
Urinary Tract Infections*;
Vesico-Ureteral Reflux
- From:Pediatric Infection & Vaccine
2015;22(1):29-35
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to investigate the clinical characteristics and outcome of febrile urinary tract infections (UTIs) caused by community-acquired extended-spectrum beta-lactamase (CA-ESBL)-producing and -nonproducing bacteria. METHODS: We analyzed febrile UTIs in children hospitalized at Gachon University Gil Medical Center from January 2011 to December 2013 through retrospective data collection from their medical records. RESULTS: Among pathogens causing 374 episodes of UTIs, the proportion of ESBL-producing bacteria was 13.1% (49/374). The proportion of ESBL-producing Escherichia coli and Klebsiella spp. was 13.6% (48/354) and 5.0% (1/20), respectively. There was no significant difference between the CA-ESBL and CA non-ESBL groups in duration of fever (4.2+/-2.7 vs.3.7+/-2.1 days, P=0.10) and bacterial eradication rate with empirical antibiotics (100% vs. 100%). The risk of cortical defects on renal scan significantly depended on existence of vesicoureteral reflux rather than ESBL production of pathogen. CONCLUSIONS: There was no significant difference between the CA-ESBL and CA non-ESBL groups in renal cortical defects and clinical outcome. Careful choice of antibiotics is important for treatment of community-acquired UTI in children.
